Paper
Reagent-free Hyperspectral Diagnosis of SARS-CoV-2 Infection in Saliva Samples
Published Jun 4, 2024 · Brandon Saint-John, Alejandro Wolf-Yadlin, Daniel E. Jacobsen
ECS Sensors Plus
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Abstract
Rapid, reagent-free pathogen-agnostic diagnostics that can be performed at the point of need are vital for preparedness against future outbreaks. Yet, many current strategies are pathogen-specific and require several reagents. We present hyperspectral sensing, using light to non-invasively measure the composition of several molecules to form a spectral signature, to overcome these barriers. To generate these spectral signatures, we present the ProSpectralTM V1, a novel, miniaturized hyperspectral platform with high spectral resolution with two mini-spectrometers. Furthermore, we developed state-of-the-art ML pipelines for near real-time analysis of spectral signatures in saliva samples. We found that we could accurately identify SARS-CoV-2 infection status in double-blinded saliva samples and demonstrate 100% accuracy on a hold out test dataset. To our knowledge, this establishes the fastest hyperspectral diagnostic platform and in a small form factor, and executable with liquid samples, without ligands or reagents, all while maintaining PCR level specificity and sensitivity.
The ProSpectralTM V1 is the fastest, reagent-free hyperspectral diagnostic platform for accurately identifying SARS-CoV-2 infection status in saliva samples, maintaining PCR level specificity and sensitivity.
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