Paper

Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing.

Published Apr 1, 2025 · Honglue Shi, Noor Al-Sayyad, Kevin Wasko

Molecular cell

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Abstract

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In Vitro Study

Study Snapshot

High-efficiency CRISPR-Cas9-guided genome editing relies on an optimized two-step target capture process, where selective but low-affinity PAM binding precedes rapid DNA unwinding.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing.

References

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