Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions

doi:10.1128/mbio.01940-24

Paper

Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions

Published Mar 20, 2025 · B. Steiert, Mary M. Weber

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Abstract

ABSTRACT Viruses and bacteria exploit the nuclear pore complex (NPC) and host nuclear functions to bypass cellular barriers and manipulate essential processes. Viruses frequently engage directly with NPC components, such as nucleoporins, to enable genome import and evade immune defenses. In contrast, bacterial pathogens rely on secreted effector proteins to disrupt nuclear transport and reprogram host transcription. These strategies reflect a remarkable evolutionary convergence, with both types of pathogens targeting the NPC and nuclear functions to promote infection. This minireview explores the overlapping and unique mechanisms by which pathogens hijack the host nucleus, shedding light on their roles in disease and potential avenues for therapeutic intervention.

Study Snapshot

Pathogens like viruses and bacteria exploit the nuclear pore complex and host nuclear functions to promote infection, offering potential avenues for therapeutic intervention.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions

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