Paper

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

Published Feb 1, 2022 · Daniel S. Simpson, J. Pang, Ashley Weir

Immunity

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Abstract

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In Vitro StudyVery Rigorous JournalHighly Cited

Study Snapshot

Interferon- primes macrophages for pathogen ligand-induced killing, which requires iNOS, potentially impacting disease severity in SARS-CoV-2 infection and other iNOS-associated inflammatory conditions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

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